The USE Method is a model for troubleshooting a system that is in distress when you don't know exactly what the nature of the problem is.
For example, if users within a specific part of your network are complaining of slowness, disconnects and poor application performance, you can probably isolate your troubleshooting to 2-3 switches or routers. However, since the problem description is so vague (we all love the "it's slow!" report, right? ?), it's hard to know where to start with detailed troubleshooting on those specific switches/routers.